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The vCAFs can produce several angiogenesis factors, such as VEGF, FGF, PDGF, and osteopontin to promote the vessel formation by recruiting myeloid cells and accelerate angiogenesis by attracting vascular endothelial cells and recruiting monocytes (94, 95)

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The general form, applicable to all the different metalcoordinated forms of SOD, can be written as follows: M (n+1)+ SOD + O 2 M n+ SOD + O 2 M n+ SOD + O 2 + 2H + M (n+1)+ SOD + H 2 O 2 The reactions by which SODcatalyzed dismutation of superoxide for Cu,Zn SOD can be written as follows: Cu 2+ SOD + O 2 Cu + SOD + O 2 (reduction of copper