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2 g intravenously per day for 30 days as an infusion

Safety considerations, particularly the risk of pseudoaldosteronism and potential drug interactions, are also discussed

mTORC2 contains Rictor in place of Raptor and therefore phosphorylates a distinct set of substrates

The most concerning complications involve muscle weakness beyond intended areas creating eyelid drooping (ptosis, 1-3% incidence), eyebrow asymmetry from uneven muscle relaxation, or frozen appearance from excessive dosing or poor injection technique, though these typically resolve as Botox wears off over 2-4 months requiring patience and potentially corrective procedures

We divided PD patients into EOPD and LOPD based on the registration at age of PD