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It has been noted (11, 12) that NADPH oxidase-mediated oxidative stress and P53 (p53 is a tumor suppressor protein that regulates the expression of a variety of genes that are involved in apoptosis, growth arrest, inhibition of cell cycle progression, differentiation and accelerated DNA repair or senescence in response to genotoxicity or cell stress.) and Bax/Bcl2-mediated apoptosis signaling pathways are involved in the pathogenesis of cataracts in diabetic rats, and Puerarin may exert a therapeutic effect on diabetic cataract rats by improving the state of insulin resistance and downregulating the level of P53 protein (12)

ROS assay DCs were given GDEs, and they were then kept in an incubator overnight at 37C with 5% CO 2

Assume that water acts as both a proton donor and acceptor in this reaction

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Advertisement Research ArticleMetabolismPulmonology Open Access | 10.1172/JCI151685 1 Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan