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Previous studies (139, 186, 189, 190) have shown that CPZ-induced male reproductive toxicity through excessive production of ROS/RNS decreases testicular dehydrogenase activity and flagellar motility as well as depletion of lipids on sperm cell membranes and testicular polyunsaturated fatty acids in protein causing increased sperm membrane destabilization and fluidization

Allergen Information Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish, tree nut, or sesame ingredients

526 Therefore, the development of targeted drugs and therapies aimed at epigenetic markers, particularly demethylation agents, holds promise for breakthroughs in the treatment of cancer cachexia