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10.1007/s00125-019-05029-y Diabetologia 152 Scheibye-KnudsenM.MitchellS

Paradoxically, endogenous SAM accumulation or exogenous SAM treatment inhibits CRC proliferation, induces apoptosis (178, 179), and reverses promoter hypomethylation of oncogenes such as c-Myc and Ras (180)

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Natural compounds should be given more thought, since they can have extended therapeutic time windows, good pharmacological targets, and little side effects