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Specifically, murine systems lack the heterogeneous donor-recipient interactions, comorbidities (e.g., diabetes, hypertension), and immunosuppressive drug effects pervasive in clinical settings

F.Bernal-MuozR.Luna-SurezS.Rosas-CrdenasF

The majority of Treg cells express the CD25 molecule (IL-2R receptor), which exhibits a high affinity for IL-2 and initiates CD25-mediated signaling through activation of the transcription factor STAT5 [154]