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We were exploring ways of developing peptides that bind selectively, and we were very successful at that, but then we confronted the problem that our short, 23-residue peptides are not promising therapeutic candidates primarily because they cannot get into cells, Keating says

They typically contain ingredients like L-citrulline, L-arginine, watermelon extract, or beetroot powder all known to support healthy blood flow and vascular health

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The pathophysiology of cerebral edema involves sulfonylurea receptor1(SUR1)-TRPM4 channels

Still massive, but no longer so unwieldy