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It has been reported that matrix metalloprotease (MMP) enzymes are responsible for the proteolytic degradation of ECM, and they play a role in invasion and metastasis due to the high expression of these MMPs in various tumor tissues (Kleiner and Stetler-Stevenson 1999)

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Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling

This hypoxic and acidic environment not only facilitates tumor invasion and metastasis but also enhances tumor resistance to anticancer therapies

Ann allergy Asthma Immunol (2000) 85(1):921