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Furthermore, cytokines and chemokines released by dying tumor cells following ADC treatment can recruit and activate various immune cells, including macrophages and natural killer (NK) cells, thereby further promoting antitumor responses (50)

, tumor protein p53 (TP53, also known as p53) and nuclear factor-B (NF-B), and activator protein 1 (AP-1)), kinases ( e.g

doi: 10.1177/00302228231174602 41 AnindhitaMHaniifahMPutriAMNKarnasihAAgianandaFYaniFFet al

Fu Y, Chen N, Wang Z, Luo S, Ding Y, Lu B

The MRT is the time it takes for drug concentration to decrease by 63.2%, so the MRT value is typically slightly greater than T