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Description

Chang C-H, Tsai W-C, Lin M-S, et al

Direct supplementation with 800 g 5-MTHF and 1000 g vitamin B12 usually produces good results

Most studies have chosen to target H3R, a presynaptic autoreceptor that regulates dopamine, acetylcholine, and histamine release via negative feedback, which has also been associated with other neurologic disorders such as Alzheimers disease and attention deficit hyperactive disorder (ADHD) [59,60]

Why These Are Given Together This formulation is designed to support cellular and mitochondrial energy production, neurological function, and cognitive clarity