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Results: In the DIO mouse model, where ALG-055009 was administered QD or BID for 28 days, dose-dependent increases in selective THR-induced liver gene expression were observed and were associated with reductions in serum total and LDL-C

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Gaucher disease is a rare autosomal recessive genetic disease that is caused by the excessive accumulation of glucose neuraminidase in macrophages because of the dysfunction and abnormal lysosomal transport of glucosaminidase 123

Mendelian randomization: can genetic epidemiology contribute to understanding environmental determinants of disease

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