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Environmental and Health Factors Affecting B12 Status: Industrial emissions including NOx Scrubber byproducts and recovery boiler stacks output Heavy Metals accumulation affecting cellular mitochondria function Nitrous oxide exposure depleting Vitamin B12 stores Medications including metformin and Proton pump inhibitors Digestive disorders such as Crohns disease , Celiac disease , and SIBO Autoimmune diseases affecting intrinsic factor production Recognizing the Symptoms of B12 Deficiency The symptoms of Vitamin B12 deficiency often develop gradually, making them easy to dismiss as normal aging or stress-related fatigue

In the same way, the depletion of LRRK2 or application of LRRK2 inhibitors decreases ROS, restores mitochondrial function, prevents mitochondrial fragmentation, and blocks increases in proapoptotic proteins including caspase 3, Bax, and apoptotic-inducing factor [53,54,55]

Increased energy production leads to increased ROS production which induces enhanced expression of enzymatic and non-enzymatic antioxidants, specifically GSTS1, Gtpx-2, Txp-1 and vitellogenin to protect against oxidative damage

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