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Developing new therapies with the target population in mind will facilitate the development of drugs that will induce a greater tumor response for individual patients

About 55% of the variability in warfarin dose could be explained by the combination of VKORC1 and CYP2C9 genotypes, age, height, body weight, interacting drugs, and indication for warfarin therapy in Caucasian patients.5Similar observations have been reported in Asian patients.6,7 The terminal half-life of warfarin after a single dose is approximately one week