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It blocks an enzyme (NNMT) that would otherwise drain a cell's NAD+, a molecule cells need for energy production

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chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide the invention encompasses a method of providing muscular therapy by co-administering a therapeutically effective amount of one or more NNMT inhibitors with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy