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They end up in the range of either receiving free radicals or acting as toxins

A rare, but life-threatening hepatic veno-occlusive disease associated with chronic administration of azathioprine has been described in transplant patients and in one patient receiving AZASAN for panuveitis.11, 12, 13 Periodic measurement of serum transaminases, alkaline phosphatase, and bilirubin is indicated for early detection of hepatotoxicity

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For example, Brazil nuts are one of the most potent source of selenium

The phase I superfamily known as flavin-containing monooxygenase, like cytochrome P450s, are found expressed at the highest levels in the endoplasmic reticulum of hepatocytes and are involved in the oxidation of nitrogen, sulfur, and phosphate moieties found in drug molecules