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It can range from simple steatosis to inflammation and fibrosis, and eventually lead to irreversible liver cirrhosis (Tanaka et al., 2020)

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Examples of altered membrane structure are Hereditary Spherocytosis and Hereditary Elliptocytosis, in which the shape of the RBC is spherical and elliptical, respectively, instead of the normal biconcave shaped cells (Da et al., 2013)