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The following dosing protocol for healing with TB-500 is not supported by any studies published thus far, but it can serve as a starting point for researchers, who are advised to begin with still lower doses and titrate upward approaching this protocol: Daily Dose: 2mg, administered subcutaneously Frequency: Daily subcutaneous injections Study Duration: 15 days Notes: Researchers need three vials of TB-500 10mg to complete this protocol

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Since the effect of inhibitors can vary with the metal ion cofactors 32 , we performed r Pf GS assays in the presence of MnCl 2 as well