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Hormonal changes during pregnancy can trigger melasma, often referred to as the "mask of pregnancy." It may fade postpartum but can persist in some cases

The proposed mechanisms involve enhanced perfusion to injured tissues, modulation of inflammatory responses, and promotion of satellite cell activation and myogenesis

The drugs listed in Table II have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline

It's this whole shell game, but it sets precedent like we covered before

No published time-course demonstrates diminishing effect, and mechanistic reviews note the absence of receptor desensitization that would predict tolerance