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A novel model for prediction of human drug clearance by allometric scaling

Rovira-Llopis et al

Three mitochondrial metabolites were regulated by the principal drug, the complement drug, and the assistant drug together

Constitutively expressed COX-1 is believed to function in physiologic, or housekeeping, activities such as vascular homeostasis, maintenance of renal and gastrointestinal blood flow, renal function, intestinal mucosal proliferation, platelet function, and antithrombogenesis

Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1