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Concurrently, in skeletal muscle, lactate can inhibit fat breakdown and promote triglyceride accumulation through the GPR81-cAMP-PKA axis, while simultaneously enhancing mitochondrial biogenesis and oxidative function through metabolic pathways [9, 151]

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Here too, inhibition of MCU-dependent presynaptic Ca 2+ uptake caused increased presynaptic cytoplasmic Ca 2+ levels and negatively affected short-term synaptic plasticity [55]

Periconceptual maternal nutrition affects fetal liver programming of energy- and lipid-related genes

In contrast, pathways involved in metabolism, such as alanine, aspartate, and glutamate metabolism, biosynthesis of secondary metabolites, and C5-branched dibasic acid metabolism, displayed a balance of upregulated and downregulated genes