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6, June 2015, p

We received public comments in response to this RFI, and we appreciate the thoughtful input

We took advantage of quantitative 33 S-NMR to measure precisely the amount of sulfur incorporated, high-resolution liquid chromatography/mass spectrometry (LC-MS) to determine populations of isotopic species (isotopologues), and gas chromatography/mass spectrometry (GC-MS) for metabolic profiling

Understanding the crosstalk between these epigenetic modifications will not only enhance our knowledge of cancer biology but also pave the way for the development of novel, targeted therapies that can effectively overcome resistance mechanisms