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65 A recent study on naturally aged mice found that in the absence of an additional trigger, the activation of cyclic GMPAMP synthase (cGAS)stimulator of interferon genes (STING) signaling pathway is sufficient to promote aging-related inflammation and neurodegeneration by triggering reactive microglial transcriptional states

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We found that etomoxir resulted in a significantly lower concentration of Cyt-c (2.69 0.22 SEM) compared to Wt+R+V mice (4.3 0.38 SEM, p = 0.01) (Fig