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Increased levels of these cytokines switch on pathways that cause muscle and bone breakdown and neuronal degeneration, accelerate atherosclerosis, and damage DNA, increasing the risk of death (Kabagambe 2011

This was explained by an ongoing further metabolism of 5-(3,4-dihydroxyphenyl)--valerolactone in blood cells (see section 6.3 Site-specific metabolism: blood cells) and confirmed by the detection of valerolactone-derived metabolites (34)

As for killers, there's also more to think about than simply chasing and killing the opposing team