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Yet this compelling mechanistic story has generated precisely zero human clinical trials for mental health applications

A member of the RAS superfamily, ADP ribosylation factor 6 (ARF6), acts as a downstream of the KRAS/extracellular signal-regulated kinase (ERK) pathway to increase the proliferation and Warburg effect of pancreatic cancer cells

10.1016/j.ymthe.2022.01.035 305

Activated STAT3 was higher expressed in the mice with 5-HT when compared with mice lack of 5-HT, which hinted that 5-HT might promote liver regeneration partially by the activation of STAT3