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Memisogullari R et al reported that glutathione peroxidase activity was significantly decreased in type II diabetes mellitus

Consistently, low-dose intranasal administration of RNs has been investigated for neuroprotection in an EAE mouse model of MS

doi: 10.1002/eji.200324833 52 ElliottD

L-Glutathione (GSH), especially in nanoparticle slow-release form, maintains redox tone but excessive co-delivery creates a reductive stress, paradoxically inactivating Nrf2, SIRT3, and AMPK, the very genes responsible for antioxidant renewal