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Although the role of xCT in neurodegeneration and neuroprotection remains paradoxical, arsenic-induced upregulation suggests its indispensability for survival in stress condition

Race-dependent differences in Lp (a) concentrations are known

Control of the nephrotoxicity of cisplatin by clinically used sulfur-containing compounds

DOX alters myocardial ETC gene expression and translation in vivo , reducing the redox cycle of the ETC complex I, and generates large amounts of ROS (56)

Rather than viewing these as competing approaches, the evidence suggests they function best as complementary strategies in maintaining cellular redox balance