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compared with morphine, it has a slower onset, a more prolonged course, and milder symptoms, all of which favor a slower detoxification taper with a decreased risk of severe withdrawal

Two TF families were overrepresented in the HRG-associated MORE cassettes, identifying them as potential HIF cooperating TF families: Kruppel-like Factor (KLF) and E26 Transformation Specific (ETS) factor (Fig