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If folate deficiency is suspected, it is reasonable to give oral folic acid (0.4 1 mg/day) without doing laboratory investigation for deficiency at least until the hemoglobin and mean corpuscular volume normalizes (or longer if the underlying cause cannot be eliminated)

Understanding Vitamin B12 and Its Importance Keeping vitamin B12 levels up is key to staying healthy

(2) in the brains reward system, certain neurons are located near glucose receptors

B12 is one important piece, but persistent exhaustion usually has more than one contributing factor