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Whiting PH, Kalansooriya A, Holbrook I, Haddad F, Jennings PE

Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

It is possible that XJP achieves this effect by participating in the caspase-3 and TGF- signaling pathways

We also look at methylmalonic acid (MMA) or homocysteine levels sometimes