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GHK-Cu plays a central role in wound healing, angiogenesis, and stem cell activation by modulating gene expressionover 4,000 genes, including those involved in cellular repair, collagen production, and antioxidant defense

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Activated microglia serve a dual role during ischemia, releasing pro-inflammatory cytokines (such as TNF- and IL-1) that can aggravate ischemic injury, whilst promoting the release of anti-inflammatory cytokines (such as IL-10) to reduce ischemic injury [2]

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Our in silico analysis predicted a flanking region of 1631/1609 bp in the PPARGC1A gene promoter (Supplemental Figure 4A)