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3 Age is also an important risk factor for T2D

Haematologica 2004

2.2 Antioxidant and Anti-Inflammatory Effects: As a copper chaperone, GHK-Cu activates superoxide dismutase (SOD), neutralizing reactive oxygen species (ROS) and protecting against oxidative damage

It enhances metalloproteinase activity, which breaks down damaged collagen so new, properly organized collagen can replace it

GCL belongs to the class of proteins that are sensitive to oxidative stress, and its expression is mainly under the regulation of the Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), a transcription factor that regulates a wide array of antioxidant responsive element-driven genes in various cell types (Baldelli et al., 2013)