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Specific enzyme activities were measured spectrophotometrically based on established protocols: NADPH oxidase according to Sarath et al

Inclusion and ethics statement The study presented here, has been approved and annually reviewed by the ethics board of the Ministry of Health of the Democratic Republic of the Congo (DRC) and the IRB board of the Oregon Health and Sciences University

This enzyme is responsible for the synthesis of the PGD 2 , which is then converted into Prostaglandin J2 (PGJ 2 ) and 15-deoxy-prostaglandin J2 (15-PGJ 2 ) 32

In the liver, homocysteine can also be converted to cysteine via the transsulfuration pathway

The study demonstrated that DGNP-coupled plasmids induced RNF41 expression in CD11b macrophages, modulating macrophage homeostasis post-liver injury [210]