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Changming Zhai, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

148,157,158 Specifically, some cancer cells, such as PDAC and CRC cells, depend on a noncanonical glutamine metabolism pathway in the cytosol under the regulation of oncogenic KRAS activation

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However, the high-iron diets or depletion of GPX4 promotes Hydroxyguanosine 8 (8-OHG) release and thus activates the TMEM173/STING-dependent DNA sensor pathway, which results in macrophage infiltration and activation during Kras-driven PDAC in mice ( An emerging oncoprotein, Myoferlin, controls mitochondria structure and respiratory functions, has been associated with a low survival in several cancer types including PDAC

Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration