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Results: DDC mice had increased AST, ALT, bilirubin, bile acids, ductular reaction and macrophage infiltration and reduced hepatocyte mRNA expression of Abcb11, Abcg8, Nr0b2 (SHP), Nr5a2 and Abcc2 mRNA relative to chow fed mice

3.3.1 Estrogen maintains mitochondrial health via the PGC-1 signaling axis, inhibiting ferroptosis One of the core mechanisms of estrogens protective effect on mitochondria is through the activation of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1), a master regulator of mitochondrial biogenesis

Oxidative stress, energy metabolism disorders, and inflammatory responses that occur during this process cause severe damage to myocardial cells

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While GHK Cu shows promising effects related to gene expression patterns connected to aging biology, it is not a substitute for foundational longevity practices such as proper nutrition, sleep, inflammation management, and metabolic health