glutathione reductase and oxidative stress Frontiers glutathione reductase removal of reactive

Melatonin Melatonin, an amphiphilic tryptophan-derived indolamine, is primarily secreted by the pineal gland and regulates circadian rhythm (110,111)

Proc Natl Acad Sci USA 91:237241 Maret W, Sandstead HH (2006) Zinc requirements and the risks and benefits of zinc supplementation

They confer protection by acting through the G-Coupled Protein Receptors (GCPR) (Jarosz et al., 2017)

doi: 10.1111/cns.12490 179 MoloneyR

An imbalance in glutathione metabolism, defined by lower GSH:GSSG, has been linked to a number of chronic diseases including feline chronic renal failure (Reference Keegan and Webb43) and in humans, cancer, neurodegenerative disorders, cystic fibrosis, viral infection, diabetes mellitus, renal failure and liver disease (Reference Wu, Fang and Yang44)