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However, due to the low binding affinity of Benzylserine and Benzylcysteine to ASCT2, high concentrations of inhibitors are required to compete for the substrate binding site

This system mediates a 1:1 exchange of extracellular cystine for intracellular glutamate, enabling cystine uptake and subsequent conversion into L-cysteine, which is used for the synthesis of GSH ( Erastin and RAS-selective lethal small molecule 3 (RSL3) are well-established ferroptosis inducers (77)

Is KLOW broader than GLOW

PMID: 20190676 [SOURCED] Gjurasin M, et al

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