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Ferrer-Vaquer et al., To determine the functional significance of canonical Wnt signaling in prosensory cells, these authors first used small molecule inhibitors of Wnt signaling in organotypic cultures of the embryonic (E12.5) cochlea and found that inhibition of Wnt signaling results in decreased proliferation of prosensory cells (Jacques et al., Sox2 -expressing prosensory domain and an increase in hair cell number

89 Restoration of the ECM to is original state re-establishes homeostasis, whilst excessive deposition of connective tissue or inadequate remodeling can result in fibrosis

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