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Recent research has shown that over 46% of people can not properly metabolize Folic Acid nor natural Folate unless it is in its activated coenzymated form ((6S)-5-Methyltetrahydrofolate MTHF)

Shoudai, K., Peters, J

Pharmacol Rep

M., Ellingson, A

In vivo experiments In vivo studies were performed on nude mice (strain CD-1, Charles River WIGA, Sulzfeld, Germany) xenotransplanted subcutaneously with PA-TU-8902 cells (107 per mouse