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Carsten Berndt: BE3259/5-1/-2, BE3259/6-1, 417677437/GRK2578), the Japan Society for the Promotion of Science (JSPS) Grants-in-Aid for Scientific Research (KAKENHI 22KK0253 and 25K01963 to Junya Ito), and the Research Commission of the Medical Faculty, Heinrich-Heine-University (2021-47 to Carsten Berndt)

Macrophages, known for their plasticity, undergo a dynamic process of polarization that is pivotal in the context of fibrosis

Without these data, even a positive skin outcome would be difficult to attribute to a specific mechanism, and a safe cumulative-dose ceiling could not be defined

15 The prototypical IC/BPS patient also may present with marked urinary urgency and frequency but because these symptoms may indicate other disorders, they do not exclusively indicate the presence of IC/BPS

It activates both GLP-1 and glucagon receptors, with the glucagon component being particularly relevant for hepatic fat metabolism -- a key differentiator that has driven its MASH development program