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Syringe Units = Volume to Draw (mL) 100 = 0.25 mL 100 = 25 units TB-500 Dosing Profile (10 mg Vial / 1 mL BAC Water) 2.5 mg Dose: Draw 25 units (0.25 mL)

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There is a need for greater transparency and alignment in how weight management RCTs are designed, conducted, and reported to help different stakeholders (e.g., clinicians, regulatory bodies, prescribers, patients, payers, and guideline developers) understand how estimated treatment effects should be interpreted