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It's not FDA-approved, is banned in sport, and is sold in an unregulated grey area with documented safety concerns including testosterone suppression and liver stress

doi: 10.1104/pp.114.243790 292 ZhuX

Its broad biological actions reinforcement of epithelial barrier integrity, modulation of immune and inflammatory pathways, and beneficial effects on gut microbial composition provide a strong mechanistic rationale for its clinical application

For instance, spatial transcriptomics has been employed to map these cellular interactions in organs such as the lung and gastrointestinal tract, providing new insights into the tissue remodeling processes that occur after IR exposure [122]

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