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863 NCOA4 mediated ferritinophagy plays a crucial role in regulating intracellular iron levels, and elevated expression of NCOA4 has been observed in the cartilage of OA patients, OA mice, and inflammatory chondrocytes

To experimentally verify that KLHL42 is a transcriptional target of MYC, we knocked down MYC in T24 and UMUC14 cells and found that KLHL42 expression was decreased at both the mRNA and protein levels in these two cell lines (Fig