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for the wave subgroup, I 2 = 11%, P = 0.32

The loss of BRCA1 and BRCA2 leads to the impairment of homologous recombination repair functions, rendering tumor cells unable to effectively repair DNA damage, consequently causing genomic instability and tumor progression ( When these cells experience DNA damage, they cannot repair it through the HRR pathway, leading to cell death (49)

NRF2, a transcription factor for stress response and beyond

10.3389/fcell.2024.1458716 118 SuyalS.ChoudhuryC.BachhawatA

Pioglitazone, a diabetes medication, may benefit selected patients with biopsy-proven NASH, but is also specialist-led and off-label , with potential risks including weight gain, fluid retention, heart failure, and increased fracture risk