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6 Therapeutic strategies targeting pathophenotypes Emerging therapeutic strategies increasingly target the oxytosis / ferroptosis pathway, a promising axis for disease modification in neurodegenerative diseases including PD

Quercetin application ameliorated the opacity induced by selenite treatment in an ex vivo rat lens model [84], as well as in an in vivo rat selenite cataract model [82,83]

Consequently, research has demonstrated that fisetin exhibits senolytic activity, which was discovered in a screen of flavonoid polyphenols in senescent human and murine fibroblasts (51, 52)

However, the mechanisms by which GATA6 loss induces endothelial injury and the subsequent development of PH has not been elucidated

The subsequent use of a variety of olefinic amino-acid side chains containing allylic heteroatoms suggested a breadth for this allylic chalcogen effect 132