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On the other hand, NPW treatment depressed the degree of lipid peroxidation, neutrophil infiltration and pro-inflammatory cytokine levels, and elevated antioxidant capacity in conjunction with the downregulation of gastric COX-1 and COX-2 mRNA levels, suggesting that improved gastric damage due to NPW could be eliminating the need for compensatory upregulation of COX enzymes

Cisplatin can down-regulate Nrf2 and HO-1 while upregulating inflammatory factors