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Sustained or repeated fluxes saturate local peroxiredoxins and glutathione pools, spill into iron-rich chromatin niches and bias toward ONOO and Fenton chemistry that disrupt transcription

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These syndromes are commonly diagnosed, depending on the type and geographic location of the practice, in referral clinics among patients both with and without evidence for prior Lyme disease in their history (90, 91)

In addition, Activator Protein-1 (AP-1) and Nuclear Factor kappa-light-chain-enhancer of activated B-cells (NF-B) are key transcription factors highly responsive to ROS and RNS