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At this point, it is unclear what the consequences of this local ROS accumulation at the ER-mitochondria MCS are, but ryanodine receptors 119 , IP 3 Rs and SERCA Ca 2+ pumps are known targets of ROS, which alter their activity 120

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In this placebo-controlled trial, half of the 126 participants (all with panic disorders) took Xanax for 8 weeks, and half were given a placebo

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Interestingly, a recent paper showed that inhibition of glucose metabolism leads to a reduction of ASCT2 glycosylation (see section Protein-protein Interactions, PTM and Structure/Function Relationships) in agreement with a refined concerted regulation of the two metabolic pathways (Polet et al., 2016)