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10.1016/S0304-4165(97)00104-9 144

5 Oxidative stress and epigenetic modifications in DR Long-term hyperglycemia triggers epigenetic modifications, which, without altering the DNA sequence, regulate gene expression through mechanisms like DNA methylation, histone modification, and noncoding RNA expression (105)

The efficacy endpoint was the rate of incident HIV-1 infections per 100 person-years in participants randomized to YEZTUGO compared with the rate of incident HIV-1 infections per 100 person-years in participants randomized to TRUVADA