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Aquilariae Lignum fraction pretreatment of LPS-stimulated BV2 microglia cells significantly reduced NO, cyclooxygenase-2 (COX-2), IL-1, and prostaglandin E2 levels and attenuated nuclear factor-kappaB (NF-B) and p65 activities [109]

434,435,436,437 The majority of phase II and III trials center around neurotransmitter receptors and A mechanisms, while tau and inflammation drugs are more prominent in phase II, often featuring repurposed compounds