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Homozygous (double variant): Both copies carry a change (e.g., C677T/C677T)

This toxicity is largely attributed to the aberrant association of PQC network components and other metastable proteins with these aggregates, including molecular chaperones, ubiquitin conjugates, proteasome subunits, the transcription coactivator cAMP response elementbinding protein (CREB)binding protein (CBP), the ATPase valosincontaining protein (VCP)/p97, and nonexpanded wild-type ATXN3 [53,54,55,56,57,58]

Human safety data are limited

4MSOB GSL is the predominant aliphatic GSL in wild-type and CYP79A2 KI plants, but is not present in myb28myb29 KO and myb28myb29 cyp79b2cyp79b3 KO plants, while indolic GSLs, such as indolyl-3-methyl (I3M) GSL, are present in wild-type, myb28myb29 KO, and CYP79A2 KI plants (Fig